Akọrọ epidermis pụtara na ihe mgbochi akpụkpọ ahụ na-akpaghasị, lipids na-efunahụ, protein na-ebelata

Mgbe nnukwu ma ọ bụ nke na-adịghị ala ala mebie ihe mgbochi epidermal, usoro nrụzi nke akpụkpọ ahụ ga-eme ka mmepụta nke keratinocytes dịkwuo ngwa, na-ebelata oge ngbanwe nke mkpụrụ ndụ epidermal, na-edozi mmepụta na ntọhapụ nke cytokines, na-akpata hyperkeratosis na obere mbufụt nke akpụkpọ ahụ. .Nke a bụkwa ụdị mgbaàmà akpụkpọ anụ.

Mfụfụ mpaghara nwekwara ike ime ka akpụkpọ ahụ dịkwuo njọ, n'ezie, nkwụsị nke ihe mgbochi epidermal na-akwalite njikọ na ntọhapụ nke usoro cytokines pro-inflammatory, dị ka IL-1he TNF, nke mere na phagocytic dịghịzi mkpụrụ ndụ, karịsịa neutrophils, na-ebibi.Mgbe a dọtara mmasị na saịtị akọrọ, mgbe ha rutere ebe ahụ, neutrophils na-ezobe leukocyte elastase, cathepsin G, protease 3, na collagenase n'ime anụ ahụ gbara ya gburugburu, na-etolite ma na-eme ka protease na keratinocytes dịkwuo elu.Nsonaazụ nwere ike ịkpata oke ọrụ protease: 1. mmebi cell;2. Ntọhapụ nke cytokines pro-inflammatory;3. Mbilite n'oge akaghi aka nke kọntaktị cell na cell na-akwalite mitosis cell.Ọrụ enzyme proteolytic na akpụkpọ anụ, nke nwekwara ike imetụta irighiri akwara na epidermis, jikọtara ya na itching na mgbu.Ngwa ngwa nke tranexamic acid na α1-antitrypsin (onye na-egbochi protease) na xerosis dị irè, na-atụ aro na xeroderma jikọtara ya na ọrụ enzyme proteolytic.

Akọrọ epidermis pụtara naa na-akpaghasị ihe mgbochi akpụkpọ ahụ, lipids na-efunahụ, protein na-ebelata, a na-ahapụkwa ihe ndị na-akpata mkpali mpaghara.Akọrọ nke akpụkpọ ahụ kpatara mmebi ihe mgbochidị iche na nkụchi nke n'ihi mbelata sebum secretion, na mmetụta nke mfe lipid supplementation na-emekarị na-emezughị atụmanya.Ihe ịchọ mma moisturize emepụtara maka mmebi ihe mgbochi kwesịrị ọ bụghị naanị ịgbakwunye stratum corneum moisturizing ihe, dị ka ceramides, ihe na-eme ka mmiri dị n'okike, wdg, kamakwa na-eburu n'uche mmetụta nke antioxidant, mgbochi mkpali, na nkewa nke cell, si otú ahụ belata ọdịiche na-ezughị ezu. nke keratinocytes.Ihe mgbochi akpụkpọ akọrọ na-esochi ya na ọzịza, yana mgbakwunye na ihe antipruritic kwesịrị ịtụle.