Mgbe mmebi dị oke njọ ma ọ bụ nke na-adịghị ala ala nke ihe mgbochi epidermal gasịrị, usoro nrụzi nke akpụkpọ ahụ na-akpaghị aka ga-eme ka mmepụta nke keratinocytes dịkwuo ngwa ngwa, belata oge nnọchi nke mkpụrụ ndụ epidermal, ma mee ka mmepụta na ntọhapụ nke cytokines dị irè, na-ebute hyperkeratosis na obere mbufụt nke akpụkpọ ahụ. Nke a bụkwa ihe a na-ahụkarị na mgbaàmà akpụkpọ ahụ kpọrọ nkụ.
Mbufụt mpaghara nwekwara ike ime ka nkụ akpụkpọ ahụ ka njọ, n'eziokwu, mmebi nke ihe mgbochi epidermal na-akwalite mmepụta na ntọhapụ nke usoro cytokines pro-inflammatory, dị ka IL-1he TNF, ka e wee bibie mkpụrụ ndụ phagocytic ji alụso ọrịa ọgụ, karịsịa neutrophils,. Mgbe a dọtara ha na ebe akọrọ, mgbe ha rutere ebe a na-aga, neutrophils na-ewepụta leukocyte elastase, cathepsin G, protease 3, na collagenase n'ime anụ ahụ gbara ya gburugburu, ma mepụta ma mee ka protease baa ụba na keratinocytes. Ihe nwere ike isi na ọrụ protease gabiga ókè pụta: 1. Mmebi mkpụrụ ndụ; 2. Ntọhapụ nke cytokines pro-inflammatory; 3. Mmebi mbụ nke kọntaktị cell-to-cell nke na-akwalite mitosis cell. Ọrụ enzyme proteolytic na akpụkpọ ahụ kpọrọ nkụ, nke nwekwara ike imetụta akwara mmetụta na epidermis, na-ejikọta ya na pruritus na mgbu. Iji tranexamic acid na α1-antitrypsin (ihe na-egbochi protease) mee xerosis dị irè, na-egosi na xeroderma jikọtara ya na ọrụ enzyme proteolytic.
Akọrọ epidermis pụtara naihe mgbochi akpụkpọ ahụ na-egbochi, lipids na-efu, protein na-ebelata, a na-ewepụtakwa ihe ndị na-akpata mbufụt n'ógbè ahụ.Akpịrị akpụkpọ ahụ nke mmebi ihe mgbochi kpataradị iche na nkụ nke mmiri sebum na-akpata, mmetụta nke mgbakwunye lipid dị mfe anaghị emezu ihe a tụrụ anya ya. Ihe ịchọ mma e ji mmiri mee maka mmebi ihe mgbochi ekwesịghị naanị ịgbakwunye ihe ndị na-eme ka mmiri dị n'ime corneum dị ka ceramides, ihe ndị na-eme ka mmiri dị n'ime eke, wdg, kamakwa iburu n'uche mmetụta nke antioxidant, anti-inflammatory, na anti-cell nkewa, si otú a belata ọdịiche zuru oke nke keratinocytes. A na-ejikarị pruritus na-esochi nkụchi akpụkpọ ahụ, a ga-atụlekwa mgbakwunye nke ihe ndị na-eme ka mmiri dị n'ime ya.
Oge ozi: Juun-10-2022
