Ihe mbụ na-akpata ịka nká akpụkpọ:
UV radieshon, fotoaging
70% nke ịka nká anụ ahụ sitere na fotoaging
Ụzarị UV na-emetụta collagen na ahụ anyị, nke na-eme ka akpụkpọ ahụ dị ka nwata. Ọ bụrụ na collagen na-adaba, akpụkpọ ahụ ga-ebelata ịdị nro, mgbakasị ahụ, isi ọwụwa, ụda akpụkpọ ahụ na-adịghị mma, hyperpigmentation, pigmentation na nsogbu akpụkpọ ndị ọzọ.
E kewara obosara nke anyanwụ ka ọ bụrụ UVA na UVB. UVB ụzarị nwere obere wavelength na nwere ike na-ere ọkụ n'elu oyi akwa nke akpụkpọ anyị, enweghị ike banye miri emi n'ime akpụkpọ; Otú ọ dị, UVA ụzarị nwere ogologo wavelengths na ike banye site na iko na miri n'ime akpụkpọ, n'ikpeazụ na-ebelata collagen na-eduga na mmepe nke wrinkles.
N'okwu dị mfe, UVA na-eduga na ịka nká, UVB na-eduga n'ọkụ, na ìhè ultraviolet nwere ike imebi DNA cellular, belata ọrụ fibroblast, na-egbochi njikọ nke collagen, na-eduga na mmụgharị cell, ịka nká, na apoptosis. Yabụ, UV nọ ebe niile, ma anwụ na-acha ma ọ bụ urukpuru, ịkwesịrị ịrụ ezigbo ọrụ nke nchekwa anyanwụ.
Ihe nke abụọ kachasị mkpa na ịka nká akpụkpọ
Oxidative free radicals
Isi okwu maka free radicals bụ 'oxygen'. Anyị na-eku ume ihe dị ka pasent 98 ruo 99 nke oxygen oge ọ bụla anyị na-eku ume; a na-eji ya gbaa nri anyị na-eri ọkụ ma na-ahapụkwa obere ụmụ irighiri ihe maka mkpụrụ ndụ anyị ka ọ na-agbaze, ọ na-ewepụtakwa ike dị ukwuu iji mee ka akwara anyị na-arụ ọrụ.
Ma eleghị anya, 1% ma ọ bụ 2% nke oxygen na-ahọrọ ụzọ dị iche iche na nke dị ize ndụ, obere ikuku oxygen a, nke a na-akpọkarị free radicals, nke na-awakpo sel anyị. Ka oge na-aga, mmebi a na-agbakọta ka oge na-aga.
Ihe kacha pụta ìhè bụ ihe ịrịba ama nke ịka nká nke na-egosi na akpụkpọ ahụ. Ahụ anyị nwere usoro nchekwa nke na-arụzi mmebi mebiri emebi nke mkpụrụ ndụ anyị site na radicals free, ma mgbe free radicals na-agbakọta ngwa ngwa karịa mkpụrụ ndụ ahụ nwere ike ịrụkwa ha, akpụkpọ ahụ ji nwayọọ nwayọọ na-aka nká.
Foto dị n'elu bụ ezigbo anụ ahụ nke anụ ahụ anyị, ị nwere ike ịhụ nke ọma na n'elu epidermis na-agba ọchịchịrị na dermis na-egbuke egbuke na-egbuke egbuke, dermis bụ ebe anyị na-emepụta collagen, na mkpụrụ ndụ ndị na-emepụta collagen na-akpọ fibroblasts, nke bụ. igwe na-eme collagen.
Fibroblasts dị n'etiti foto a bụ fibroblasts, na ududo udide gburugburu ha bụ collagen. A na-emepụta collagen site na fibroblasts, na akpụkpọ ahụ na-eto eto bụ netwọk collagen nwere akụkụ atọ nke jikọtara ya nke ọma, nke nwere fibroblasts na-adọta ike na eriri collagen iji nye akpụkpọ ahụ na-eto eto ọdịdị zuru oke ma dị nro.
Na akpụkpọ ahụ ochie, fibroblasts na collagen njikọ n'etiti mgbasa nke ịka nká fibroblasts ga-ajụkarị ntinye nke collagen, ka oge na-aga, akpụkpọ ahụ malitekwara ịka nká, nke a bụ ihe anyị na-ekwukarị na ịka nká, olee otú anyị si edozi oxidation nke ahụ. akpụkpọ natara?
Na mgbakwunye na ịṅa ntị nke ọma na sunscreen, anyị nwere ike iji ụfọdụ nwere vitamin A, vitamin E, ferulic acid, resveratrol na ihe ndị ọzọ nke ngwaahịa nlekọta anụ ahụ; na-enwekarị ike iri mkpụrụ osisi na akwụkwọ nri na-egbuke egbuke, dị ka tomato, tomato bara ụba na lycopene.
Ọ nwere ike ịmịkọrọ oxygen nke ọma ma gbochie nrụgide oxidative, ị nwekwara ike rie ọtụtụ broccoli, broccoli nwere akụkụ a na-akpọ mustard oil glycosides, mgbe ọ risịrị ihe a, a ga-echekwa ya na akpụkpọ ahụ, ka mkpụrụ ndụ akpụkpọ ahụ wee nwee ike ichebe onwe ya. , mkpụrụ osisi na akwụkwọ nri ndị a nwere ike ịkwalite mgbochi cell na ịka nká.
Ihe nke atọ kachasị mkpa na ịka nká akpụkpọ
Akpụkpọ ahụ glycation
Glycation, na usoro ọkachamara, a na-akpọ mmeghachi omume glycosylation na-abụghị enzymatic ma ọ bụ mmeghachi omume Melad. Ụkpụrụ bụ na ibelata shuga na-ejikọta na protein na enweghị enzymes; Mbelata shuga na-agbanwe nke ukwuu site na protein, yana ibelata shuga na protein na-enweta ogologo oge oxidation, dehydrogenation, na mmeghachi omume nhazigharị, na-ebute mmepụta nke ngwaahịa njedebe glycosylation n'oge, ma ọ bụ AGEs maka mkpụmkpụ.
AGE bụ otu ihe mkpofu ihe na-adịghị agbanwe agbanwe, nke na-acha odo odo na-acha aja aja, na-adịghị atụ egwu mbibi nke enzyme, ma bụrụ otu n'ime isi ihe na-akpata ịka nká mmadụ. Ka anyị na-akawanye nká, AGEs na-agbakọta n'ime ahụ, na-eduga n'ịbawanye ike nke mgbidi dị n'ime arịa ọbara, enweghị ahaghị nhata nke ọkpụkpụ ọkpụkpụ nke na-eduga osteoporosis, na mbibi nke collagen na elastin fibers na dermis na-eduga n'ịka nká. A na-achịkọta ịka nká akpụkpọ nke glycation kpatara n'otu ahịrịokwu: shuga na-ebibi protein ndị dị mma ma na-agbanwe usoro protein ndị na-eto eto ka ọ bụrụ protein ochie, na-eduga na ịka nká na nkwụsị nke collagen na eriri na-agbanwe na dermis.
Oge nzipu: Mee-29-2024
